Low Dose Naltrexone is a once-daily compounded capsule, reviewed by a US-licensed provider and delivered discreetly to your door. A gentle, widely studied option for people living with chronic pain, autoimmune symptoms, and low energy.
At its standard 50 mg dose, naltrexone is FDA-approved for addiction. At a much lower 0.5 to 4.5 mg dose taken nightly, it works differently: it nudges your body to make more of its own endorphins and helps quiet the overactive immune signaling (via the TLR4 receptor) linked to inflammation. Because it is not sold at these strengths, it is custom-compounded for you.
Compounded to your strengthA fraction of the standard 50 mg dose, built up gradually by your provider.
Most people take it before bed. Simple to fit into a daily routine.
Made to order by a licensed compounding pharmacy in your prescribed strength.
Prescribed at a provider's discretion. Not FDA-approved at these low doses.
Two well-described pathways help explain why a tiny nightly dose can have a body-wide effect.
The brief nightly block prompts your body to make more of its own endorphins and enkephalins. Many people associate higher endorphin activity with steadier mood, energy, and a calmer response to pain.
By acting on the TLR4 receptor, LDN is thought to quiet overactive microglia, the immune cells of the nervous system. Lowering that low-grade inflammation is why LDN is studied in pain and autoimmune conditions.
These mechanisms are well described in the research literature. How much each contributes to any individual's experience is still being studied.
LDN is used off-label, meaning a provider may consider it for uses beyond its original approval. People most often ask about it in these areas. Whether it is right for you is a clinical decision made after reviewing your health.
Including fibromyalgia, nerve pain such as CRPS and neuropathy, and migraine prevention. The most studied use.
Discussed alongside Hashimoto's, rheumatoid arthritis, Crohn's and ulcerative colitis, MS, lupus, psoriasis, and Sjogren's.
For ME/CFS (chronic fatigue syndrome) and the persistent feeling of running on empty.
Early research is exploring LDN for lingering fatigue and brain fog after a viral illness.
Where low-grade, body-wide inflammation plays a role, including MCAS and conditions like endometriosis.
Explored as an add-on for mood, depression support, and sleep, within a broader wellbeing plan.
LDN is studied for these uses, not proven to treat or cure them. Evidence is strongest for chronic pain and varies by condition. Your provider will discuss what is realistic for your situation.
LDN is introduced gradually so your body can adjust comfortably. Here is the RightMD build-up to a 3 mg maintenance dose, taken once each night.
A gentle starting dose to ease in.
First step up, taken once before bed.
Continuing the gradual build.
Easing toward your maintenance dose.
Your maintenance dose for the rest of the 90-day supply.
This gentle build to a 3 mg maintenance dose lets your body adjust comfortably, and your provider can go slower if you need to. Vivid dreams early on? Switching to a morning dose usually settles it.
From first click to front door in four straightforward steps. Most people finish the online visit in just a few minutes.
Choose Low Dose Naltrexone to begin your online visit.
Answer a short, private set of medical questions about your health and goals.
A US-licensed provider reviews your information and, if appropriate, prescribes LDN.
Your compounded prescription is prepared and shipped discreetly, with easy refills.
At these low doses LDN is considered well tolerated for most people. Here is what to know, and what to tell your provider.
Yes. LDN is a prescription medication. With RightMD you complete a short online visit, and a US-licensed provider decides whether it is appropriate for you. There is no separate paperwork for you to chase down.
Naltrexone is FDA-approved at its standard 50 mg dose for alcohol and opioid dependence. At the low 0.5 to 4.5 mg doses described here, it is used off-label and is custom-compounded. Compounded medications are not reviewed by the FDA for safety or effectiveness, and your provider will talk through what that means for you.
LDN is taken once a day by mouth, most often at night. With RightMD you start at 0.5 mg and step up gradually every two weeks (0.5, then 1, 1.5, 2.25, and 3 mg), reaching a 3 mg maintenance dose over about eight weeks. Your provider personalizes the exact schedule for you.
LDN is not a fast-acting medication. Many people begin to notice changes over four to eight weeks, and it can take up to about twelve weeks to feel the full effect as the dose is adjusted. Patience during the early titration is normal.
At low doses LDN is generally well tolerated. The most common effect is vivid dreams in the first week, along with possible mild sleep changes, headache, or stomach upset that usually settle quickly. Taking your dose in the morning instead of at night often resolves the dream and sleep effects.
LDN should not be combined with opioid medications, including some prescription pain relievers and cough medicines, because it can cause withdrawal. It is also typically paused before surgery or procedures that need opioid pain relief. Tell your provider about all medications you take.
Naltrexone is only manufactured commercially as a 50 mg tablet. The low doses used for LDN simply are not available off the shelf, so they must be specially prepared, or compounded, by a licensed pharmacy to the strength your provider prescribes.
Possibly. Because naltrexone is processed by the liver, your provider may check your liver function before you start or from time to time during treatment, especially if you have any liver history. They will tell you what, if anything, is needed for you.
LDN is generally not appropriate for anyone currently using opioid medications, and your provider will take extra care if you are pregnant or breastfeeding, have significant liver concerns, or take thyroid medication. A licensed provider reviews your history to confirm it is a safe option for you.
Transparent, all-inclusive pricing. Every plan includes your US-licensed provider review, compounded medication, and discreet shipping. No insurance needed.
A gentle first month to ease in
The full 90-day protocol
Compounded LDN is generally not covered by insurance, so pricing is simple and cash-based. Your provider confirms the right plan for you before anything ships.
Start your online visit today and let a US-licensed provider decide if Low Dose Naltrexone is right for you. Plans from $99, with prescription, medication, and shipping included.
Order NowThis page is for general educational purposes only and is not medical advice. Low Dose Naltrexone is prescribed off-label at the low doses described here and is custom-compounded; the FDA does not review compounded medications for safety or effectiveness. LDN is studied for the uses mentioned but is not proven, and individual results vary. These statements have not been evaluated by the FDA, and LDN is not intended to diagnose, treat, cure, or prevent any disease. A prescription is issued only if a US-licensed provider determines it is appropriate after reviewing your health information; payment does not guarantee a prescription. Available in eligible states. Always follow the directions of your provider and pharmacy. If you have a medical emergency, call your local emergency number.
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